Endothelial protective effects of preconditioning
نویسندگان
چکیده
منابع مشابه
ndothelial protective effects of preconditioning *
The consequences of cardiac ischemia–reperfusion are not limited to myocytes but also extend to the coronary endothelium, where they are characterized by decreased nitric oxide (NO)-dependent relaxations. Given the essential role of the endothelium and NO in the regulation of vascular tone as well as platelet and leukocyte function, protection of coronary endothelial cells is an important thera...
متن کاملEndothelial nitric oxide contributes to the renal protective effects of ischemic preconditioning.
We determined whether endothelial nitric oxide synthase (eNOS) plays an important role in the renal protective effect of ischemic preconditioning (IP) against the ischemia/reperfusion-induced acute renal failure (ARF) by using eNOS-deficient (eNOS(-/-)) and wild-type (eNOS(+/+)) mice. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 w...
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To use Langendorff model to investigate whether remote ischemic preconditioning (RIPC) attenuates post-ischemic mechanical dysfunction on isolated rat heart and to explore possible mechanisms. SD rats were randomly divided into RIPC group, RIPC + norepinephrine (NE) depletion group, RIPC + pertussis toxin (PTX) pretreatment group, ischemia/reperfusion group without treatment (ischemia group) an...
متن کاملEvidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning.
Preconditioning the heart with brief periods of ischaemia induces delayed endothelial protection against reperfusion injury, but the precise mechanisms involved in this endogenous protein are still unclear. Induction of the type II-nitric oxide synthase (iNOS) acts as a mediator of the preconditioning against myocardial infarction and stunning. The present study was designed to assess whether i...
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THE IDEA THAT EXPOSURE TO sublethal ischemia could confer protection against a subsequent ischemic insult goes back at least as far as 1989, when Miyazaki and Zipes (13) reported that a sequence of four 5-min coronary occlusions reduced the autonomic denervation produced by a subsequent coronary occlusion in dog hearts. This idea rapidly gained popularity, and, in 1994, Kato et al. (10) reporte...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2002
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(02)00277-8